Systematic review of treatments for the gastrointestinal manifestations of systemic lupus erythematosus

Abstract

OBJECTIVES: To comprehensively assess and present the evidence for treatments used in the management of the gastrointestinal manifestations of SLE. METHODS: A systematic search of the literature from January 1990 to June 2022 was performed using the following databases: MEDLINE, EMBASE, PubMed and Cochrane. Key words relating to the gastrointestinal system, SLE, and treatment were used. Where there was sufficient evidence for the treatment of a manifestation, we excluded case series with <10 cases and case reports. However, for rarer manifestations with insufficient higher-level evidence, smaller case series and case reports were included. RESULTS: A total of 29 studies including 767 patient..